Anti-CDX4 (AB1) antibody produced in rabbit
SIGMA/AV32765 - affinity isolated antibody
Synonym: Anti-Caudal type homeobox transcription factor 4
Product Type: Chemical
Immunohistochemistry Anti-CDX4 (ab1): Cat. No. AV32765: Immunohistochemistry of CDX4 in Human Pancreas tissue with CDX4 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-CDX4 (ab1): Cat. No. AV32765: Immunohistochemistry of CDX4 in Human Pancreas tissue with CDX4 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV32765). Lanes 1. Antibody dilution (concentration) 2.5 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 30 kDa |
| NCBI accession no. | NP_005184   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, dog, rabbit, pig, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O14627 |
| Application: | Rabbit Anti-CDX4 (AB1) antibody can be used for western blot applications at a concentration of 2.5 μg/ml. |
| Biochem/physiol Actions: | CDX are homeodomain transcription factors related to the Drosophila caudal gene. The vertebrate CDX have been implicated in the development of the posterior embryo. Several signaling molecules, notably retinoic acid (RA) and members of the Wnt (wingless) and fibroblast growth factor (FGF) families, are also implicated in patterning of the posterior vertebrate embryo. CDX family is the target of Wnt, RA and FGF signaling, suggesting that CDX factors act to convey the activity of these signaling molecules to Hox genes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Caudal related homeobox (Cdx) genes are known to modulate axial elongation and patterning in many vertebrate embryos. Cdx4 regulates the ontogenesis of placental labyrinth in mice. Furthermore, Cdx4 is known to dysregulate Hox gene expression which causes acute myeloid leukemia in mouse models. Rabbit Anti-CDX4 antibody recognizes rat, mouse, bovine, and human CDX4. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human CDX4 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: KKISQFENSGGSVQSDSDSISPGEL |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |