Anti-RUNX1 antibody produced in rabbit
SIGMA/AV38073 - affinity isolated antibody
Synonym: Anti-Runt-elated transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
Product Type: Chemical
Immunoblotting Cell Type: Jurkat (Cat. No. AV38073). Lanes 1. Antibody dilution (concentration) 0.25 μg/mL in cell type Jurkat
Western Blotting Western Blot of RUNX1 in Mouse Brain with RUNX1 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 12 kDa |
| NCBI accession no. | NP_001001890   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, bovine, guinea pig, dog, rabbit, human, rat, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q01196 |
| Application: | Anti-RUNX1 antibody produced in rabbit is suitable for western blot. |
| Biochem/physiol Actions: | RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities. In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays an important role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c. Structurally, it consists of Runt domain at the N-terminal region. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human RUNX1 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: KMPAAPRGPAQGEAAARTRSRDAST |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |