Anti-SNCA (Ab-129) antibody produced in rabbit
SIGMA/SAB4300445 - affinity isolated antibody
Synonym: Anti-MGC110988 antibody produced in rabbit; Anti-NACP antibody produced in rabbit; Anti-PARK1 antibody produced in rabbit; Anti-PARK4 antibody produced in rabbit; Anti-synuclein, alpha (non A4 component of amyloid precursor) antibody produced in rabbit
MDL Number: MFCD02095740
Product Type: Chemical
Immunoblotting Anti-SNCA (Ab-129): SAB4300445: Analysis of extracts from mouse brain tissue using Anti-SNCA (Ab-129) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (M-P-S-E-E) |
| isotype | IgG |
| mol wt | ~18 kDa |
| NCBI accession no. | NP_000336.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | P37840 |
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| General description: | SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons. |
| Immunogen: | Peptide sequence around aa. 127-131 (M-P-S-E-E), according to the protein SNCA. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |