Synonym: (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol; 1α,24R-dihydroxycholecalciferol; 1α,24R-dihydroxyvitamin D3
CAS Number: 57333-96-7
Empirical Formula (Hill Notation): C27H44O3
Molecular Weight: 416.64
MDL Number: MFCD00866623
Linear Formula: C27H44O3
Product Type: Chemical
| assay |
≥99% (HPLC) |
| biological source |
synthetic (organic) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 |
| InChI key |
BJYLYJCXYAMOFT-RSFVBTMBSA-N |
| Quality Level |
200  |
| SMILES string |
C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=CC=C3C[C@@H](O)C[C@H](O)C3=C |
| storage temp. |
−20°C |
| technique(s) |
HPLC: suitable |
| Biochem/physiol Actions: |
Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease. |
| General description: |
Tacalcitol is a synthetic vitamin D3 analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3. |
| Packaging: |
1 mg in glass bottle |
| Symbol |
 GHS06 |
| Signal word |
Danger |
| Hazard statements |
H300 |
| Precautionary statements |
P301 + P330 + P331 + P310 |
| RIDADR |
UN 2811 6.1 / PGI |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥99% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352205 |
