7DG

SIGMA/SML0806 - ≥95% (HPLC)

Synonym: 7-Desacetoxy-6,7-dehydrogedunin

CAS Number: 26927-01-5
Empirical Formula (Hill Notation): C₂₆H₃₀O₅
Molecular Weight: 422.51
Linear Formula: C₂₆H₃₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0806-1MG	1 mg	$78.10 1/EA		Add To Favorites
45-SML0806-5MG	5 mg	$303.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to beige
form	powder
Quality Level	100
shipped in	wet ice
solubility	DMSO: 5 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC₅₀) of 5 μM, showing a role for PKR in pyroptosis.
Features and Benefits:	This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.
Packaging:	1, 5 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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