Tarocin A1
SIGMA/SML1677 - ≥98% (HPLC)
Synonym: (4S,5R)
Empirical Formula (Hill Notation): C24H18F6N2O3
Molecular Weight: 496.40
Linear Formula: C24H18F6N2O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C24H18F6N2O3/c1-13-21( |
InChI key | XWMRKUPNQVITEC-ZSEKCTLFSA |
Quality Level | 100 |
SMILES string | C[C@H](N1C(CCC2=C(C=CC=C3 |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis. Tarocin A1 has an IC50 value of 40 nM in a biochemical TarO assay. Tarocin A does not inhibit bacterial growth alone, and exhibits no cytotoxicity against HeLa cells, but it has potent bactericidal syergism with broad spectrum β-lactams, and may restore the clinical efficacy of existing β-lactam antibiotics. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P302 + P352 - P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |