c-JUN (1-79), GST tagged human
SIGMA/SRP5176 - recombinant, expressed in E. coli, ≥50% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: AP1
CAS Number: 913305-50-7
Product Type: Chemical
application(s) | cell analysis |
assay | ≥50% (SDS-PAGE) |
biological source | human |
form | buffered aqueous glycerol solution |
mol wt | ~35 kDa |
NCBI accession no. | NM_002228 |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage temp. | −70°C |
General description: | c-Jun is a proto-oncogene that forms a complex with c-Fos which regulates transcription from promoters containing AP-1 activation elements. c-Jun has specific DNA binding activity and following in vitro translation, c-Jun binds as a homodimer to the AP-1 DNA site. The transactivating function of c-Jun is acutely regulated by a wide variety of cellular signals via modulation of phosphorylation of two serines (63 and 73). Jun N-terminal domain kinases (JNKs), are responsible for mediating S63/73 phosphorylation on c-Jun in response to a variety of cellular stimuli including TNF-a, heat stress and u.v. light. |
Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥50% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |