(S)-(−)-Warfarin
SIGMA/UC214 - ≥97% (HPLC)
Synonym: S-(−)-3-Acetonybenzyl)-4-hydroxycoumarin; S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
CAS Number: 5543-57-7
Empirical Formula (Hill Notation): C19H16O4
Molecular Weight: 308.33
EC Number: 226-907-3
MDL Number: MFCD00272381
Linear Formula: C19H16O4
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to pale yellow |
| form | solid |
| InChI | 1S/C19H16O4/c1-12(20)11-1 |
| InChI key | PJVWKTKQMONHTI-HNNXBMFYSA |
| mp | ≥170 °C |
| SMILES string | [H][C@](CC(C)=O)(c1ccccc1 |
| storage temp. | 2-8°C |
| Application: | (S)-(−)-Warfarin has been used in cell cultures. |
| Application: | Studies using (R)-(+)-warfarin have reported that it can upregulate hepatic CYP3A4 and CYP2C. It has also been used in HepG2 cells to study protein profiles. |
| Biochem/physiol Actions: | CYP2C9 substrate; anticoagulant. |
| Biochem/physiol Actions: | Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9) protein plays a major role in the inactivation of potent S-warfarin. |
| General description: | Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant. |
| Packaging: | 5, 10 mg in glass bottle |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360D - H372 - H412 |
| Precautionary statements | P201 - P273 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61-48/25-52/53 |
| Safety Statements | 53-45-61 |
| RIDADR | UN 2811 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| mp | ≥170 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12161501 |