Corning® BioCoat™ Smooth Muscle Cell Differentiation Environment

An in vitro system optimized for the differentiation of human and rat SMC. Includes specially formulated Corning BioCoat™ Growth Factor Reduced (GFR) Matrigel™ Matrix Cellware and serum-free Smooth Muscle Differentation Medium.

• Three-dimensional matrix promotes differentiated (contractile) SMC phenotype, low proliferative index, nodular morphology and ultrastructure dominated by microtubules and microfilaments
• Expression of cytoskeletal markers, α-smooth muscle actin, heavy chain myosin, and 150 kD h-caldesmon
• Carry out studies of SMC specific function two weeks earlier than Collagen I
• Reduced levels of growth factors for cytokine studies
• Serum-free environment maximizes control over experimental conditions

Complete protocol provides:

• Standardized procedures
• Capability for immediate start-up

Applications:

Corning Matrigel™ Matrix has been used to culture SMC for studies of:

• SMC differentiation
• Modulation of SMC function
• Molecular mechanisms of phenotypic transitions
• Effects of various compounds on SMC behavior
• Effects of ECM proteins on vascular SMC phenotype

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Cat.No.	Brand	Name	Type	Treated	Number of Wells	Material	Well Shape	Color	Lid	Growth Area	Sterile	Packaging	Addl. Info.	CS
3-354635	BioCoat™		Smooth muscle cell differentiation environment	Y	24	Polystyrene	Flat	Clear	Y	2.0cm²	N	Pack of 5	Matrigel™ coated	$0.00 5/CS CALL FOR PRICE		Add To Favorites