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Fetuin from fetal bovine serum

SIGMA/F2379 - lyophilized powder, suitable for cell culture

Synonym: Fetuin from fetal calf serum

CAS Number: 9014-81-7
EC Number: 232-762-7
MDL Number: MFCD00131055
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-F2379-100MG 100 mg
$58.90
1/EA
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45-F2379-250MG 250 mg
$76.60
1/EA
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45-F2379-1G 1 g
$274.00
1/EA
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45-F2379-5G 5 g
$974.00
1/EA
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45-F2379-25G 25 g
$3740.00
1/EA
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F2379-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F2379-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F2379-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F2379-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F2379-1G

 

biological source bovine serum (fetal)
form lyophilized powder
impurities ≤0.3% free N-acetylneuraminic acid
Quality Level 200 
solubility H2O: 1 mg/mL, colorless to faint yellow or tan
storage temp. 2-8°C
technique(s) cell culture | mammalian: suitable
UniProt accession no. Q58D62 
Application: Fetuin from fetal bovine serum has been used:
• to synthesize primary and secondary calciprotein particles (CPP)
• to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
• as a supplement in Ham′s F10 media for myoblast culture.

Application: Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
Biochem/physiol Actions: Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.
General description: Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.
Packaging: 1, 5, 25 g in poly bottle
Packaging: 100, 250 mg in poly bottle
Preparation Note: Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 12352202

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