Fetuin from fetal bovine serum
SIGMA/F3385 - lyophilized powder, BioReagent, suitable for cell culture
Synonym: Fetuin from fetal calf serum
CAS Number: 9014-81-7
EC Number: 232-762-7
MDL Number: MFCD00131055
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F3385-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F3385-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F3385-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F3385-1G
| form | lyophilized powder |
| impurities | ≤0.3% free N-acetylneuraminic acid |
| mol wt | 48.4 kDa |
| product line | BioReagent |
| Quality Level | 200  |
| solubility | H2O: 1 mg/mL |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Fetuin from fetal bovine serum has been used: • as a substrate to determine neuraminidase activity • to validate the specificity of sialidases • to stabilize m-calpain |
| Biochem/physiol Actions: | Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism. Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases. Fetuin exhibits anti-inflammatory property. |
| General description: | Fetuin from fetal bovine serum is a plasma glycoprotein. It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue. A glycoprotein derived from FBS that is used as Fetuin has been used at a concentration of 500 mg/ml to supplement serum free F12 medium (along with insulin, transferrin and 2-mercaptoethanol) in culture of embryonal carcinoma cells. |
| Packaging: | 1, 5, 25 g in poly bottle |
| Packaging: | 100 mg in poly bottle |
| Preparation Note: | Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |