Anti-TMEM119 antibody produced in rabbit
SIGMA/HPA051870 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Tmem119 Antibody; Tmem119 Antibody - Anti-TMEM119 antibody produced in rabbit; Anti-transmembrane protein 119
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
conjugate | unconjugated |
enhanced validation | independent orthogonal RNAseq Learn more about Antibody Enhanced Validation |
form | buffered aqueous glycerol solution |
immunogen sequence | GDGARMVEGRGAEEEEKGSQEGDQE |
product line | Prestige Antibodies® Powered by Atlas Antibodies |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | human |
storage temp. | −20°C |
target post-translational modification | unmodified |
technique(s) | immunohistochemistry: 1:500-1:1000 |
UniProt accession no. | Q4V9L6 |
Application: | Anti-TMEM119 antibody produced in rabbit has been used in immunohistochemistry. |
Biochem/physiol Actions: | Transmembrane protein 119 (TMEM119) acts as an osteoinductive factor and facilitates proliferation, migration and invasion of osteosarcoma cells.(28} It is a critical molecule acting downstream of the parathyroid hormone (PTH) and similar to mothers against decapentaplegic-3 (Smad3) signaling pathways in osteoblasts. TMEM119 is considered to be a potential microglial marker that differentiates resident microglia from blood-derived macrophages in the human brain. Mutation in the gene is associated with the development of osteosarcoma. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
General description: | Transmembrane protein 119 (TMEM119) is encoded by the gene mapped to human chromosome 12q23.3. The encoded protein belongs to the transmembrane protein family. TMEM119 has an O-glycosylated N-terminal region. |
Immunogen: | transmembrane protein 119 recombinant protein epitope signature tag (PrEST) |
Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
Linkage: | Corresponding Antigen APREST85802 |
Physical form: | Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Storage Temp. | −20°C |
UNSPSC | 12352203 |