Albumin, Nitrated from bovine serum
SIGMA/N8159 - lyophilized powder
Synonym: Nitrated BSA
CAS Number: 9048-46-8
MDL Number: MFCD03454307
Product Type: Chemical
Bovine serum albumin is a protein which has a key role in regulating blood colloidal osmotic pressure. Six α-helices form three homologous domains of BSA.
| biological source | bovine |
| form | lyophilized powder |
| Quality Level | 200  |
| shipped in | wet ice |
| storage temp. | −20°C |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | P02769  |
| Analysis Note: | Does not contain sodium azide |
| Application: | Positive control in immunoblotting assays for Anti-Nitrotyrosine (Sigma Product Number N 0409). |
| Biochem/physiol Actions: | Peroxynitrite promotes the nitration of tyrosine residues in proteins linked, oxidation of redox metal centers, DNA, lipids and nitrosation of cysteine residues in proteins, suggesting that peroxynitrite plays a major role in oxidative cellular damage. Peroxynitrite has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human disease. These include neurological conditions such as Alzheimer′s disease, amyotrophic lateral sclerosis (ALS), the pathogenesis of asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Albumin, Nitrated (Nitrated BSA), is prepared by chemical modification of bovine serum albumin (BSA) by peroxynitrite. Peroxynitrite (ONOO-), a potent oxidant is an important member of the family of reactive oxygen and nitrogen species. |
| Physical form: | Lyophilized from 0.01 M phosphate buffered saline, pH 7.4 |
| Preparation Note: | Bovine serum albumin (BSA) nitrated with peroxynitrite. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |