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Anti-Glucagon antibody, Mouse monoclonal

SIGMA/SAB4200685 - clone K79bB10, purified from hybridoma cell culture

Synonym: Monoclonal Anti-Glucagon antibody produced in mouse; GCG; GLP1; GLP2; GRPP

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SAB4200685-25UL 25 µL
$174.00
1/EA
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45-SAB4200685-100UL 100 µL
$514.00
1/EA
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Immunohistochemistry Staining of formalin-fixed, paraffin-embedded rat pancrease sections with 10 μg/mL Monoclonal Anti-Glucagon, Clone: K79bB10 (Cat. No. SAB4200685). The antibody was developed using biotin/ExtrAvidin®-Peroxidase.

 

antibody form purified immunoglobulin
antibody product type primary antibodies
biological source mouse
clone K79bB10, monoclonal
concentration ~1 mg/mL
form buffered aqueous solution
isotype IgG1
packaging antibody small pack of 25 μL
Quality Level 200 
shipped in dry ice
species reactivity cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
storage temp. −20°C
target post-translational modification unmodified
technique(s) immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin®-Peroxidase staining system.
  radioimmunoassay: suitable
Application: Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).
Biochem/physiol Actions: The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description: Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).
Immunogen: Polymerized porcine glucagon
Legal Information: ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Storage Temp. −20°C
UNSPSC 51111800

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