Harmane
ALDRICH/103276 - 98%
Synonym: 1-Methyl-9H-pyrido[3,4-b]indole; 2-Methyl-β-carboline; Aribine
CAS Number: 486-84-0
Empirical Formula (Hill Notation): C12H10N2
Molecular Weight: 182.22
EC Number: 207-642-2
MDL Number: MFCD00004957
Linear Formula: C12H10N2
Product Type: Chemical
| assay | 98% |
| drug control | stupéfiant (France) |
| InChI | 1S/C12H10N2/c1-8-12-10(6- |
| InChI key | PSFDQSOCUJVVGF-UHFFFAOYSA |
| mp | 235-238 °C (lit.) |
| Quality Level | 100  |
| SMILES string | Cc1nccc2c3ccccc3[nH]c12 |
| solubility | methanol: soluble 50mg/ml |
| Application: | • Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry. • It was used to study interactions of norharman and harman with DNA. • It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix. |
| Biochem/physiol Actions: | I1 imidazoline binding site agonist. |
| General description: | • Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin. • It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures. • Blood harmane concentration is elevated in essential tremor, late-life neurological disease. |
| Packaging: | 1 g in glass bottle |
| Preparation Note: | Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 98% |
| mp | 235-238 °C (lit.) |
| UNSPSC | 12352100 |