HBTU

ALDRICH/12804 - ≥98.0% (T)

Synonym: N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate; O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate

CAS Number: 94790-37-1
Empirical Formula (Hill Notation): C₁₁H₁₆F₆N₅OP
Molecular Weight: 379.24
EC Number: 423-020-5
MDL Number: MFCD00075445
Linear Formula: C₁₁H₁₆F₆N₅OP
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-12804-1G-F	1 g	$53.90 1/EAAdd To Favorites	Add To Favorites
45-12804-5G-F	5 g	$106.00 1/EAAdd To Favorites	Add To Favorites
45-12804-25G-F	25 g	$338.00 1/EAAdd To Favorites	Add To Favorites

application(s)	peptide synthesis
assay	≥98.0% (T)
form	solid
functional group	amine
InChI	1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChI key	UQYZFNUUOSSNKT-UHFFFAOYSA-N
mp	200 °C (dec.) (lit.)
Quality Level	200
reaction suitability	reaction type: Coupling Reactions
SMILES string	F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccccc12)=[N+](/C)C
solubility	acetonitrile: 0.1 g/mL, clear
storage temp.	2-8°C

Application:	HBTU is a peptide coupling agent for peptide synthesis. It has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol.
Application:	Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.
General description:	HBTU is a peptide coupling agent used in Fmoc-based solid-phase peptide synthesis.
Packaging:	1, 5, 25 g in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H317 - H335
Precautionary statements	P261 - P264 - P271 - P272 - P280 - P302 + P352
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	22-26-36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.0% (T)
mp	200 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	12352107