Synonym: N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate; O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
CAS Number: 94790-37-1
Empirical Formula (Hill Notation): C11H16F6N5OP
Molecular Weight: 379.24
EC Number: 423-020-5
MDL Number: MFCD00075445
Linear Formula: C11H16F6N5OP
Product Type: Chemical
| application(s) |
peptide synthesis |
| assay |
≥98.0% (T) |
| form |
solid |
| InChI |
1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1 |
| InChI key |
UQYZFNUUOSSNKT-UHFFFAOYSA-N |
| mp |
200 °C (dec.) (lit.) |
| Quality Level |
200  |
| reaction suitability |
reaction type: Coupling Reactions |
| SMILES string |
F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccccc12)=[N+](/C)C |
| solubility |
acetonitrile: 0.1 g/mL, clear |
| storage temp. |
2-8°C |
| Application: |
HBTU is a peptide coupling agent for peptide synthesis. It has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol. |
| Application: |
Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields. |
| Packaging: |
1, 5, 25 g in glass bottle |
| Purity |
≥98.0% (T) |
| mp |
200 °C (dec.) (lit.) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352107 |
GHS07