HBTU
ALDRICH/12804 - ≥98.0% (T)
Synonym: N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate; O-
CAS Number: 94790-37-1
Empirical Formula (Hill Notation): C11H16F6N5OP
Molecular Weight: 379.24
EC Number: 423-020-5
MDL Number: MFCD00075445
Linear Formula: C11H16F6N5OP
Product Type: Chemical
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| application(s) | peptide synthesis |
| assay | ≥98.0% (T) |
| form | solid |
| functional group | amine |
| InChI | 1S/C11H16N5O.F6P/c1-14(2) |
| InChI key | UQYZFNUUOSSNKT-UHFFFAOYSA |
| mp | 200 °C (dec.) (lit.) |
| Quality Level | 200  |
| reaction suitability | reaction type: Coupling Reactions |
| SMILES string | F[P-](F)(F)(F)(F)F.CN(C)C |
| solubility | acetonitrile: 0.1 g/mL, clear |
| storage temp. | 2-8°C |
| Application: | HBTU is a peptide coupling agent for peptide synthesis. It has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol. |
| Application: | Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields. |
| General description: | HBTU is a peptide coupling agent used in Fmoc-based solid-phase peptide synthesis. |
| Packaging: | 1, 5, 25 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H317 - H335 |
| Precautionary statements | P261 - P264 - P271 - P272 - P280 - P302 + P352 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 22-26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.0% (T) |
| mp | 200 °C (dec.) (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352107 |