(1R,2S)-(−)-Ephedrine

ALDRICH/134910 - 98%

Synonym: (−)-Ephedrine; (1R,2S)-(−)-α-(1-Methylaminoethyl)benzyl alcohol; (1R,2S)-(−)-2-Methylamino-1-phenyl-1-propanol; L-α-(1-Methylaminoethyl)benzyl alcohol

CAS Number: 299-42-3
Empirical Formula (Hill Notation): C₁₀H₁₅NO
Molecular Weight: 165.23
EC Number: 206-080-5
MDL Number: MFCD00064257
Linear Formula: C₆H₅CH[CH(NHCH₃)CH₃]OH
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-134910-25G	25 g	$466.00 1/EAAdd To Favorites	Add To Favorites
45-134910-100G	100 g	$1340.00 1/EAAdd To Favorites	Add To Favorites

assay	98%
bp	255 °C (lit.)
density	1.124 g/mL at 25 °C (lit.)
form	solid
functional group	amine
	hydroxyl
	phenyl
InChI	1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChI key	KWGRBVOPPLSCSI-WPRPVWTQSA-N
mp	37-39 °C (lit.)
optical activity	[α]21/D −41°, c = 5 in 1 M HCl
Quality Level	200
SMILES string	CN[C@@H](C)[C@H](O)c1ccccc1
storage temp.	2-8°C

Application:	(1R,2S)-(-)-Ephedrine can be used in the preparation of optically active phosphine-phosphonite ligands and chirally-substituted cyclopentadienyl (Cp) ligands. It reacts with phosphorus trichloride to form (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine. It can also act as a chiral resolving agent for (±)-mandelic acid.
Application:	Versatile chiral synthon, employed in catalysis and in the preparation of optically pure sulfoxides and oxazolidines.
General description:	(1R,2S)-(-)-Ephedrine, a chiral β-amino alcohol, is commonly used as a chiral auxiliary in asymmetric synthesis. It undergoes reduction to form (+)-methamphetamine.
Packaging:	25, 100 g in glass bottle

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H302 - H314 - H317
Precautionary statements	P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-25
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	186.8 °F - closed cup
Flash Point(C)	86 °C - closed cup

Purity	98%
bp	255 °C (lit.)
mp	37-39 °C (lit.)
Density	1.124 g/mL at 25 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352116