Chloromethyl pivalate

ALDRICH/141186 - 97%

Synonym: POM-Cl; Pivaloyloxymethyl chloride

CAS Number: 18997-19-8
Empirical Formula (Hill Notation): C₆H₁₁ClO₂
Molecular Weight: 150.60
EC Number: 242-735-1
MDL Number: MFCD00000884
Linear Formula: (CH₃)₃CCOOCH₂Cl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-141186-25G	25 g	$57.10 1/EAAdd To Favorites		Add To Favorites
45-141186-100G	100 g	$90.10 1/EAAdd To Favorites		Add To Favorites

assay	97%
bp	146-148 °C (lit.)
density	1.045 g/mL at 25 °C (lit.)
form	liquid
functional group	chloro
	ester
InChI	1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3
InChI key	GGRHYQCXXYLUTL-UHFFFAOYSA-N
Quality Level	200
refractive index	n20/D 1.417 (lit.)
SMILES string	CC(C)(C)C(=O)OCCl

Application:	Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.
General description:	Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.
Packaging:	25, 100 g in glass bottle

Symbol	GHS02,GHS07
Signal word	Warning
Hazard statements	H226 - H302 + H312 + H332 - H315 - H319 - H335
Precautionary statements	P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	10-20/21/22-36/37/38
Safety Statements	16-26-36
RIDADR	UN 3272 3 / PGIII
WGK Germany	WGK 3
Flash Point(F)	104.0 °F - closed cup
Flash Point(C)	40 °C - closed cup