4-Nitrophenyl chloroformate
ALDRICH/160210 - 96%
Synonym: Chloroformic acid 4-nitrophenyl ester
CAS Number: 7693-46-1
Empirical Formula (Hill Notation): C7H4ClNO4
Molecular Weight: 201.56
EC Number: 231-706-9
MDL Number: MFCD00007321
Linear Formula: ClCO2C6H4NO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 160210-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 160210-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 160210-5G
| application(s) | peptide synthesis |
| assay | 96% |
| bp | 159-162 °C/19 mmHg (lit.) |
| form | powder |
| InChI | 1S/C7H4ClNO4/c8-7(10)13-6 |
| InChI key | NXLNNXIXOYSCMB-UHFFFAOYSA |
| mp | 77-79 °C (lit.) |
| Quality Level | 200  |
| reaction suitability | reaction type: Carbonylations |
| SMILES string | [O-][N+](=O)c1ccc(OC(Cl)= |
| storage temp. | 2-8°C |
| Application: | 4-Nitrophenyl chloroformate is used as:• A coupling agent to link the drug molecule with the polyrotaxane carrier molecule • As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF) |
| General description: | 4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides. |
| Packaging: | 5, 25, 100 g in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H314 - H335 |
| Precautionary statements | P260 - P271 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 34-36/37 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3261 8 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 230.0 °F |
| Flash Point(C) | > 110 °C |
| Purity | 96% |
| bp | 159-162 °C/19 mmHg (lit.) |
| mp | 77-79 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352108 |