Trifluoromethanesulfonic anhydride
ALDRICH/176176 - 99%
Synonym: Triflic anhydride
CAS Number: 358-23-6
Empirical Formula (Hill Notation): C2F6O5S2
Molecular Weight: 282.14
EC Number: 206-616-8
MDL Number: MFCD00000408
Linear Formula: (CF3SO2)2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 176176-1KG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 176176-500G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 176176-50G
| assay | 99% |
| bp | 81-83 °C (lit.) |
| density | 1.677 g/mL at 25 °C (lit.) |
| form | liquid |
| InChI | 1S/C2F6O5S2/c3-1(4,5)14(9 |
| InChI key | WJKHJLXJJJATHN-UHFFFAOYSA |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | FC(F)(F)S(=O)(=O)OS(=O)(= |
| vapor density | 5.2 (vs air) |
| vapor pressure | 8 mmHg ( 20 °C) |
| Application: | Catalyst for glycosylation for synthesis of polysaccharides Reagent for stereoselective synthesis of mannosazide methyl uronate donors Activator for direct glycosylation with anomeric hydroxy sugars |
| Application: | Trifluoromethanesulfonic anhydride can be used as : • A Reactant in the synthesis of Dipentaerythritol hexatriflate via triflatation method and Azido-diphenyl-acetic acid. • Catalyst for glycosylation for synthesis of polysaccharides. • Reagent for stereoselective synthesis of mannosazide methyl uronate donors. • Activator for direct glycosylation with anomeric hydroxy sugars • A methylation reagent to synthesize trifluoromethylated compounds by direct introduction of CF3 group to (hetero)arenes. • A reagent to prepare substituted tetrazoles from secondary amides using sodium azide. • A reagent in Bischler−Napieraiski cyclization reaction along with 4-(N,N-dimethylamnino)pyridine. |
| General description: | Trifluoromethanesulfonic anhydride, also known as triflic anhydride, is an electrophilic reagent that is an efficient source of trifluoromethyl. It is commonly used in organic chemistry to convert oxygen-containing compounds to triflates and for the electrophilic activation and subsequent conversion of amides, sulfoxides, and phosphorus oxides. |
| Packaging: | 1, 4 kg in glass bottle |
| Packaging: | 5, 10 g in ampule |
| Packaging: | 50, 250, 500 g in glass bottle |
| Symbol |    GHS03,GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H272 - H302 - H314 - H335 |
| Precautionary statements | P210 - P220 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 |
| Hazard Codes | C |
| Risk Statements | 14-22-35 |
| Safety Statements | 26-36/37/39-43-45 |
| RIDADR | UN 3265 8 / PGII |
| WGK Germany | WGK 3 |
| Supplemental Hazard Statements | EUH014 |
| Purity | 99% |
| bp | 81-83 °C (lit.) |
| Density | 1.677 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352101 |