Hydrogen fluoride pyridine
ALDRICH/184225 - pyridine ~30 %, hydrogen fluoride ~70 %
Synonym: HF-Pyridine; Olah′s reagent; PPHF; Poly(pyridine fluoride); Pyridine hydrofluoride; Pyridinium poly(hydrogen fluoride); Pyridinium polybifluoride
CAS Number: 62778-11-4
MDL Number: MFCD00012436
Product Type: Chemical
| composition | hydrogen fluoride, ~70% |
| pyridine, ~30% | |
| density | 1.1 g/mL at 20 °C (lit.) |
| form | liquid |
| InChI | 1S/C5H5N.FH/c1-2-4-6-5-3- |
| InChI key | GRJJQCWNZGRKAU-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | F[H].c1ccncc1 |
| storage temp. | −20°C |
| Application: | Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes. Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolane |
| Application: | Reactant for preparation of: • Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction • Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure • Candidates for nucleic acid drugs • ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorin Reagent for: • Halofluorination reactions |
| General description: | May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values. |
| Legal Information: | Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Legal Information: | Sure/Pac is a trademark of Sigma-Aldrich Co. LLC |
| Packaging: | 25, 100 g in poly bottle |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 - H314 |
| Precautionary statements | P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T+,C |
| Risk Statements | 26/27/28-35-52 |
| Safety Statements | 26-28-35-36/37/39-45-61 |
| RIDADR | UN 1790A2 6.1(8) / PGI |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.1 g/mL at 20 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352301 |