p-Toluenesulfonylmethyl isocyanide
ALDRICH/188204 - 98%
Synonym: (p-Tolylsulfonyl)methyl isocyanide; TosMIC; Tosylmethyl isocyanide
CAS Number: 36635-61-7
Empirical Formula (Hill Notation): C9H9NO2S
Molecular Weight: 195.24
EC Number: 253-140-1
MDL Number: MFCD00000005
Linear Formula: CH3C6H4SO2CH2NC
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 188204-25G
| assay | 98% |
| form | solid |
| InChI | 1S/C9H9NO2S/c1-8-3-5-9(6- |
| InChI key | CFOAUYCPAUGDFF-UHFFFAOYSA |
| mp | 109-113 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Cc1ccc(cc1)S(=O)(=O)C[N+] |
| solubility | water: slightly soluble |
| storage temp. | 2-8°C |
| Application: | p-Toluenesulfonylmethyl isocyanide was used: • in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton • as reagent in the preparation of biologically active pyrroles and imidazoles • as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes |
| General description: | p-Toluenesulfonylmethyl isocyanide undergoes base-promoted 1,3-dipolar cycloaddition reaction with immobilized imines under microwave irradiation to yield 1,5-disubstituted imidazoles. It is a versatile synthon in organic chemistry, extensively used for the synthesis of heterocyclic compounds. |
| Packaging: | 5, 25 g in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 |
| Precautionary statements | P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Supplemental Hazard Statements | EUH032 |
| Purity | 98% |
| mp | 109-113 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352100 |