7-Aminocephalosporanic acid

ALDRICH/191140 - 98%

Synonym: 7-ACA

CAS Number: 957-68-6
Empirical Formula (Hill Notation): C₁₀H₁₂N₂O₅S
Molecular Weight: 272.28
EC Number: 213-485-0
MDL Number: MFCD00005177
Linear Formula: C₁₀H₁₂N₂O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-191140-5G	5 g	$62.60 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 191140-5G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
application(s)	peptide synthesis
assay	98%
form	powder
InChI	1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1
InChI key	HSHGZXNAXBPPDL-HZGVNTEJSA-N
mode of action	cell wall synthesis \| interferes
mp	>300 °C (lit.)
optical activity	[α]19/D +90°, c = 0.5 in KH₂PO₄/trace NaOH
Quality Level	200
reaction suitability	reaction type: solution phase peptide synthesis
SMILES string	[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O
storage temp.	2-8°C

Application:	7-Aminocephalosporanic acid (7-ACA) can be used as a starting material to synthesize: • Cefotaxime by acylation reaction with S-benzothiazol-2-yl(2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM) in the presence of triethylamine. • Cefpodoxime proxetil, a third-generation antibiotic via cefotaxime intermediate. • Sodium 3′-substituted cephalosporanate sulfone derivatives as potential inhibitors of β-lactamase.
Application:	Potent inhibitor of bacterial (S. aureus) β-lactamase.
General description:	Chemical structure: ß-lactam
Packaging:	5 g in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98%
mp	>300 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352106

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