Methyllithium solution
ALDRICH/197343 - 1.6 M in diethyl ether
Synonym: Lithium methanide; MeLi
CAS Number: 917-54-4
Empirical Formula (Hill Notation): CH3Li
Molecular Weight: 21.98
MDL Number: MFCD00008253
Linear Formula: CH3Li
Product Type: Chemical
25 mL Sure/Seal™ Packaging
4×100 Pull-top Can
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
| composition | halide, ~0.05 M |
| concentration | 1.6 M in diethyl ether |
| density | 0.732 g/mL at 25 °C |
| form | liquid |
| InChI | 1S/CH3.Li/h1H3; |
| InChI key | DVSDBMFJEQPWNO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Li]C |
| storage temp. | 2-8°C |
| vapor density | 3 (vs air) |
| Application: | Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (−)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydro |
| General description: | Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile. |
| Legal Information: | Sure/Seal is a trademark of Sigma-Aldrich Co. LLC |
| Packaging: | 1 L in Sure/Seal™ |
| Packaging: | 4×25, 50, 100, 4×100, 800 mL in Sure/Seal™ |
| Packaging: | 8, 18 L in Kilo-Lab™ |
| Packaging: | The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product. |
| Packaging: | View returnable container options . |
| Symbol |    GHS02,GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H225 - H250 - H260 - H302 - H314 - H336 |
| Precautionary statements | P210 - P222 - P223 - P231 + P232 - P370 + P378 - P422 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-15-19-22-36/38-66-67 |
| Safety Statements | 16-26-43 |
| RIDADR | UN 3394 4.3(4.2) / PGI |
| WGK Germany | WGK 1 |
| Flash Point(F) | 1.4 °F - closed cup |
| Flash Point(C) | -17 °C - closed cup |
| Supplemental Hazard Statements | EUH019 - EUH066 |
| Density | 0.732 g/mL at 25 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352103 |