2-Bromohexadecanoic acid

ALDRICH/21604 - ≥99.0% (GC)

Synonym: 2-Bromopalmitic acid

CAS Number: 18263-25-7
Empirical Formula (Hill Notation): C₁₆H₃₁BrO₂
Molecular Weight: 335.32
EC Number: 242-137-0
MDL Number: MFCD00004215
Linear Formula: CH₃(CH₂)₁₃CH(Br)CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-21604-1G	1 g	$112.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (GC)
form	solid
functional group	bromo
	carboxylic acid
InChI	1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
InChI key	DPRAYRYQQAXQPE-UHFFFAOYSA-N
mp	52-54 °C
Quality Level	200
SMILES string	CCCCCCCCCCCCCCC(Br)C(O)=O
solubility	chloroform: soluble
	ethanol: soluble
	methanol: soluble 1 g/10 mL, clear, colorless
	water: insoluble

Application:	<ul> <li><strong>Chemo-immunotherapy Applications:</strong> 2-Bromohexadecanoic acid has been utilized to create bioactive fatty acid analog-derived hybrid nanoparticles for chemo-immunotherapy against carcinoma, demonstrating potential in cancer treatment without the need for antibodies (Tan et al., 2023).</A> <li><strong>Drug Target Identification for Coronavirus:</strong> 2-bromopalmitate (2-BP) can be used as an inhibitor and is used to suppressed SADS-CoV treatment (Luo et al., 2021).</A> <li><strong>Cancer Therapy Enhancement:</strong> This compound has shown efficacy in sensitizing osteosarcoma cells to adriamycin-induced apoptosis through modulation of CHOP, indicating its therapeutic potential in enhancing cancer treatment (Xu et al., 2019).</A> <li><strong>Membrane Protein Localization in Sertoli Cells: </strong>It has been involved in studies related to the localization of the androgen receptor to plasma membranes by binding to caveolin-1 in mouse Sertoli cells, contributing to the understanding of cellular signaling pathways. It is Used to inhibit palmitoylation of androgen receptor (AR) and used to evaluate the effect of the inhibitor on androgen receptor (AR) translocation (Deng et al., 2017).</A> <li><strong>Palmitoylation Inhibition:</strong> 2-Bromohexadecanoic acid has been profiled as an irreversible inhibitor of palmitoylation, providing insights into the regulation of protein modifications and their implications in various diseases (Davda et al., 2013).</A> </ul>
General description:	2-Bromohexadecanoic acid, also known as 2-Bromopalmitic acid, is a long chain 2-haloalkanoic halogenated fatty acid that is commonly used as a building block in various organic reaction such as 2′-(2-bromohexadecanoyl)-docetaxel synthesis.
Packaging:	1 g in glass bottle

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	235.4 °F - closed cup
Flash Point(C)	113 °C - closed cup

Purity	≥99.0% (GC)
mp	52-54 °C
UNSPSC	12352100

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