Tetrabutylammonium fluoride solution
ALDRICH/216143 - 1.0 M in THF
Synonym: TBAF solution
CAS Number: 429-41-4
Empirical Formula (Hill Notation): C16H36FN
Molecular Weight: 261.46
MDL Number: MFCD00011747
Linear Formula: [CH3(CH2)3]4NF
Product Type: Chemical
4×100 Slip-cover Can
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
| concentration | 1.0 M in THF |
| density | 0.903 g/mL at 25 °C |
| form | liquid |
| impurities | ~5 wt. % water |
| InChI | 1S/C16H36N.FH/c1-5-9-13-1 |
| InChI key | FPGGTKZVZWFYPV-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | [F-].CCCC[N+](CCCC)(CCCC) |
| storage temp. | 2-8°C |
| Application: | Reactant for preparation of: • Triple monoamine reuptake inhibitors as a new generation of antidepressants • Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions • Oligoribonucleotides with phosphonate-modified linkages • Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride • Conjugated dienoic acid esters using Suzuki coupling reactions • Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity • Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors • Anti-diabetic polyacetylenic glucosides |
| Application: | Tetrabutylammonium fluoride (TBAF) can be used as a reagent: • For the deprotection of silyl and N-sulfonyl groups. • In the fluorination reactions. • To synthesize 2-substituted indoles by cyclization reaction of various 2-ethynylanilines with terminal alkynes using Pd catalyst. It can also be used as an activator in the synthesis of arylated or alkenylated alkynes by the coupling reaction of aryl and alkenyl halides with terminal alkynes in the presence of Pd catalyst. |
| Packaging: | 1 L in Sure/Seal™ |
| Packaging: | 2, 2.5 L in glass bottle |
| Packaging: | 5 mL in glass bottle |
| Packaging: | 50, 100, 4×100, 500 mL in Sure/Seal™ |
| Symbol |     GHS02,GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H225 - H302 - H315 - H319 - H335 - H336 - H351 - H411 |
| Precautionary statements | P210 - P273 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | F,C |
| Risk Statements | 11-19-34-37-40 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | UN 2924 8(3) / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 1.4 °F - closed cup |
| Flash Point(C) | -17 °C - closed cup |
| Supplemental Hazard Statements | EUH019 - EUH032 |
| Density | 0.903 g/mL at 25 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352116 |