Tetrakis(triphenylphosphine)palladium(0)

ALDRICH/216666 - 99%

Synonym: Palladium-tetrakis(triphenylphosphine); Pd(PPh₃)₄

CAS Number: 14221-01-3
Empirical Formula (Hill Notation): C₇₂H₆₀P₄Pd
Molecular Weight: 1155.56
EC Number: 238-086-9
MDL Number: MFCD00010012
Linear Formula: Pd[(C₆H₅)₃P]₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-216666-1G	1 g	$44.50 1/EA	Add To Favorites
45-216666-5G	5 g	$112.00 1/EA	Add To Favorites
45-216666-25G	25 g	$535.00 1/EA	Add To Favorites
45-216666-4X25G	25 g	$1580.00 4/EA	Add To Favorites

Tetrakis

Pd(PPh₃)₄ catalyst

Properties
Descriptions
Safety Info.
Basic Data

assay	99%
form	solid
InChI	1S/4C18H15P.Pd/c41-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;/h41-15H;
InChI key	NFHFRUOZVGFOOS-UHFFFAOYSA-N
parameter	air sensitive
Quality Level	200
reaction suitability	core: palladium
	reaction type: Cross Couplings
	reaction type: Heck Reaction
	reaction type: Hiyama Coupling
	reaction type: Negishi Coupling
	reaction type: Sonogashira Coupling
	reaction type: Stille Coupling
	reaction type: Suzuki-Miyaura Coupling
	reagent type: catalyst reaction type: Buchwald-Hartwig Cross Coupling Reaction
SMILES string	[Pd].c1ccc(cc1)P(c2ccccc2)c3ccccc3.c4ccc(cc4)P(c5ccccc5)c6ccccc6.c7ccc(cc7)P(c8ccccc8)c9ccccc9.c%10ccc(cc%10)P(c%11ccccc%11)c%12ccccc%12
storage temp.	2-8°C

Application:	Application Guide for Palladium Catalyzed Cross-Coupling Reactions
Application:	Tetrakis(triphenylphosphine)palladium(0) can be used as a catalyst in: • Negishi coupling (eq. 1), Suzuki coupling (eq. 2), Stille coupling (eq. 3), Sonogashira coupling reaction (eq. 4), and Buchwald-Hartwig amination reaction (eq. 5) • The carbonylation of vinyl iodides (eq. 6) • The reduction reaction of aryl bromides (eq. 7) • Carbon-tin bond formation (eq. 8)
General description:	Palladium-tetrakis(triphenylphosphine) (Pd(PPh₃)₄) iscoordination complex of palladium and is widely used palladium cross-coupling catalyst. These applications include Negishi coupling, Suzuki coupling, Stille coupling, Sonogashira coupling, and Buchwald-Hartwig amination reactions. Tetrakis(triphenylphosphine)palladium(0) (Pd(PPh₃)₄) is a commonly used palladium(0) complex in chemical synthesis. It plays a vital role as a catalyst in various organic reactions, especially C-C, C-N, C-O, and C-heteroatom cross-coupling reactions. Pd(PPh₃)₄ finds extensive application in carbon-carbon bond-forming reactions such as the famous Heck, Suzuki-Miyaura, and Stille reactions. These reactions involve the coupling of aryl, alkyl, or vinyl halides with other organic compounds to yield valuable products. The catalytic cycle involves the oxidative addition of the organic halide to palladium(0), transmetalation with a suitable organometallic reagent or boronic acid, and reductive elimination to form the desired product. Pd(PPh₃)₄ has also been utilized in various other transformations including allylic substitutions, nucleophilic additions to alkenes and alkynes, and cycloadditions.
Packaging:	1, 5, 25, 4×25 g in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H317 - H413
Precautionary statements	P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	99%
Storage Temp.	2-8°C
UNSPSC	12352300

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