Lithium bis(trimethylsilyl)amide solution
ALDRICH/225770 - 1.0 M in THF
Synonym: Hexamethyldisilazane lithium salt
CAS Number: 4039-32-1
Empirical Formula (Hill Notation): C6H18LiNSi2
Molecular Weight: 167.33
MDL Number: MFCD00008261
Linear Formula: [(CH3)3Si]2NLi
Product Type: Chemical
25 mL Sure/Seal™ Packaging
4×100 Slip-cover Can
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
| concentration | 1.0 M in THF |
| density | 0.891 g/mL at 25 °C |
| form | liquid |
| InChI | 1S/C6H18NSi2.Li/c1-8(2,3) |
| InChI key | YNESATAKKCNGOF-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | [Li]N([Si](C)(C)C)[Si](C) |
| Application: | Lithium bis(trimethylsilyl)amide solution (1.0 M in THF) can be used as a base:• To catalyze polymerization reaction in the synthesis of poly(p-benzamide)s. • In the synthesis of cyclic poly(α-peptoid)s and α-(difluoromethyl)styrene • In directed aldol condensations and Darzens condensation reactions; α-arylation of aryl ester derivatives and allylic amination reaction. • For the generation of kinetic enolates than sodium hexamethyldisilazide (NaHMDS) because the enolates produced are more regiostable than those produced with NaHMDS. |
| General description: | Lithium bis(trimethylsilyl)amide (LHMDS) is a non-nucleophilic strong base widely used in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is generally soluble in most nonpolar organic solvents. |
| Legal Information: | Sure/Seal is a trademark of Sigma-Aldrich Co. LLC |
| Packaging: | 1 L in Sure/Seal™ |
| Packaging: | 4×25, 100, 4×100, 800 mL in Sure/Seal™ |
| Packaging: | 8, 18 L in Kilo-Lab™ |
| Packaging: | The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product. |
| Packaging: | View returnable container options . |
| Symbol |     GHS02,GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H251 - H314 - H335 - H336 - H351 |
| Precautionary statements | P210 - P235 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | F,C |
| Risk Statements | 11-14-19-34-37-40 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | UN 2924 8(3) / PGII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 1.4 °F - closed cup |
| Flash Point(C) | -17 °C - closed cup |
| Supplemental Hazard Statements | EUH014 - EUH019 |
| Density | 0.891 g/mL at 25 °C |
| UNSPSC | 12352111 |