Sodium bis(trimethylsilyl)amide solution

ALDRICH/245585 - 1.0 M in THF

Synonym: Hexamethyldisilazane sodium salt solution

CAS Number: 1070-89-9
Empirical Formula (Hill Notation): C₆H₁₈NNaSi₂
Molecular Weight: 183.37
MDL Number: MFCD00009835
Linear Formula: [(CH₃)₃Si]₂NNa
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-245585-4X25ML	25 mL	$64.60 4/EA		Add To Favorites
45-245585-100ML	100 mL	$68.10 1/EA		Add To Favorites
45-245585-4X100ML	100 mL	$213.00 4/EA		Add To Favorites
45-245585-800ML	800 mL	$315.00 1/EA		Add To Favorites
45-245585-18L	18 L	$3400.00 1/EA		Add To Favorites

25 mL Sure/Seal™ Packaging

Properties
Descriptions
Safety Info.
Basic Data

concentration	1.0 M in THF
density	0.904 g/mL at 25 °C
form	liquid
InChI	1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChI key	WRIKHQLVHPKCJU-UHFFFAOYSA-N
Quality Level	200
SMILES string	C[Si](C)(C)N([Na])[Si](C)(C)C

Application:	NaHMDS can be used as a base: • In the synthesis of N-boc-1-amino-1,3-diene derivatives from N-boc-1-amino-4-methoxy-2-alkenes via 1,4-elimination reactions. • To deprotonate alkyl or aryl ketones to generate enolate derivatives by hydroxylation reaction. • In the enantioselective synthesis of 1,2-amino alcohols by the reaction between various nitroalkanes and aldehydes via nitroaldol reaction promoted by bimetallic heterogeneous catalyst.
General description:	Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.
Legal Information:	Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
Packaging:	18, 20 L in steel drum
Packaging:	4×25, 100, 4×100, 800 mL in Sure/Seal™
Packaging:	The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Symbol	GHS02,GHS05,GHS07,GHS08
Signal word	Danger
Hazard statements	H225 - H314 - H335 - H336 - H351
Precautionary statements	P201 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	F,C
Risk Statements	11-14-19-34-37-40
Safety Statements	16-26-36/37/39-45
RIDADR	UN 2924 8(3) / PGII
WGK Germany	WGK 2
Flash Point(F)	1.4 °F - closed cup
Flash Point(C)	-17 °C - closed cup
Supplemental Hazard Statements	EUH014 - EUH018 - EUH019

Density	0.904 g/mL at 25 °C
UNSPSC	12352111

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