Lithium diisopropylamide
ALDRICH/246611 - 97%
Synonym: LDA
CAS Number: 4111-54-0
Empirical Formula (Hill Notation): C6H14LiN
Molecular Weight: 107.12
EC Number: 223-893-0
MDL Number: MFCD00064449
Linear Formula: [(CH3)2CH]2NLi
Product Type: Chemical
assay | 97% |
density | 0.864 g/mL at 25 °C (lit.) |
form | solid |
InChI | 1S/C6H14N.Li/c1-5(2)7-6(3 |
InChI key | ZCSHNCUQKCANBX-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | [Li]N(C(C)C)C(C)C |
vapor density | >1 (vs air) |
Application: | Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds. It can also be used as a base in: • The direct alkylation and acylation of ketones. • The aldol condensation reaction. • α-Selenation reaction. • The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds. • The alkylation of acids, esters, amides, and nitriles. • The initiation of anionic polymerization. |
General description: | Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran. |
Packaging: | 25, 100 g in glass bottle |
Symbol | GHS02,GHS05 |
Signal word | Danger |
Hazard statements | H250 - H314 |
Precautionary statements | P222 - P231 - P280 - P305 + P351 + P338 - P310 - P422 |
Hazard Codes | F,C |
Risk Statements | 63-14-17-62 |
Safety Statements | 26-36/37/39-43-45 |
RIDADR | UN 3393 4.2(4.3) |
WGK Germany | WGK 3 |
Flash Point(F) | 10.4 °F - closed cup |
Flash Point(C) | -12 °C - closed cup |
Purity | 97% |
Density | 0.864 g/mL at 25 °C (lit.) |
UNSPSC | 12352001 |