Lithium diisopropylamide
ALDRICH/246611 - 97%
Synonym: LDA
CAS Number: 4111-54-0
Empirical Formula (Hill Notation): C6H14LiN
Molecular Weight: 107.12
EC Number: 223-893-0
MDL Number: MFCD00064449
Linear Formula: [(CH3)2CH]2NLi
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 246611-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 246611-25G
| assay | 97% |
| density | 0.864 g/mL at 25 °C (lit.) |
| form | solid |
| functional group | amine |
| InChI | 1S/C6H14N.Li/c1-5(2)7-6(3 |
| InChI key | ZCSHNCUQKCANBX-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Li]N(C(C)C)C(C)C |
| vapor density | >1 (vs air) |
| Application: | Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds. It can also be used as a base in: • The direct alkylation and acylation of ketones. • The aldol condensation reaction. • α-Selenation reaction. • The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds. • The alkylation of acids, esters, amides, and nitriles. • The initiation of anionic polymerization. |
| General description: | Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran. |
| Packaging: | 25, 100 g in glass bottle |
| Symbol |   GHS02,GHS05 |
| Signal word | Danger |
| Hazard statements | H250 - H314 |
| Precautionary statements | P222 - P231 - P280 - P305 + P351 + P338 - P310 - P422 |
| Hazard Codes | F,C |
| Risk Statements | 63-14-17-62 |
| Safety Statements | 26-36/37/39-43-45 |
| RIDADR | UN 3393 4.2(4.3) |
| WGK Germany | WGK 3 |
| Flash Point(F) | 10.4 °F - closed cup |
| Flash Point(C) | -12 °C - closed cup |
| Purity | 97% |
| Density | 0.864 g/mL at 25 °C (lit.) |
| UNSPSC | 12352001 |