2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite

ALDRICH/305995 - 97%

Synonym: Bis(diisopropylamino)(2-cyanoethoxy)phosphine

CAS Number: 102691-36-1
Empirical Formula (Hill Notation): C₁₅H₃₂N₃OP
Molecular Weight: 301.41
MDL Number: MFCD00012213
Linear Formula: {[(CH₃)₂CH]₂N}₂POCH₂CH₂CN
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-305995-1G	1 g	$93.60 1/EA	Add To Favorites
45-305995-5G	5 g	$196.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 305995-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	97%
bp	100 °C/0.5 mmHg (lit.)
density	0.949 g/mL at 25 °C (lit.)
form	liquid
InChI	1S/C15H32N3OP/c1-12(2)17(13(3)4)20(19-11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3
InChI key	RKVHNYJPIXOHRW-UHFFFAOYSA-N
refractive index	n20/D 1.470 (lit.)
SMILES string	CC(C)N(C(C)C)P(OCCC#N)N(C(C)C)C(C)C
storage temp.	−20°C

Application:

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite was used:
• in preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotide
• as phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserine
• in situ preparation of deoxyribonucleoside phosphoramidites
• in preparation of 2′-deoxy-2′-fluoro-3′-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5′-O-(4-methoxytrityl)-4′-thio-β-D-arabinouridine and 1-(3-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4′-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymine
• as reagent for synthesizing phosphitylated nucleotides

Packaging:

1, 5 g in glass bottle

Symbol	GHS02,GHS07
Signal word	Warning
Hazard statements	H226 - H302 - H317 - H412
Precautionary statements	P210 - P233 - P273 - P280 - P301 + P312 - P303 + P361 + P353
Hazard Codes	Xn
Risk Statements	36/38-42/43
Safety Statements	3-23-26-36/37-45
RIDADR	UN 1993C 3 / PGIII
WGK Germany	WGK 2
Flash Point(F)	119.3 °F - closed cup
Flash Point(C)	48.5 °C - closed cup

Purity	97%
bp	100 °C/0.5 mmHg (lit.)
Density	0.949 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.470 (lit.)
Storage Temp.	−20°C
UNSPSC	12352100

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