Triphosgene

ALDRICH/330752 - reagent grade, 98%

Synonym: Bis(trichloromethyl) carbonate

CAS Number: 32315-10-9
Empirical Formula (Hill Notation): C₃Cl₆O₃
Molecular Weight: 296.75
EC Number: 250-986-3
MDL Number: MFCD00062848
Linear Formula: Cl₃COCOOCCl₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-330752-5G	5 g	$73.80 1/EA	Add To Favorites
45-330752-25G	25 g	$158.00 1/EA	Add To Favorites
45-330752-100G	100 g	$534.00 1/EA	Add To Favorites
45-330752-500G	500 g	$1100.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 330752-500G

Properties
Descriptions
Safety Info.
Basic Data

assay	98%
bp	203-206 °C (lit.)
form	powder
grade	reagent grade
InChI	1S/C3Cl6O3/c4-2(5,6)11-1(10)12-3(7,8)9
InChI key	UCPYLLCMEDAXFR-UHFFFAOYSA-N
mp	79-83 °C (lit.)
reaction suitability	reaction type: Coupling Reactions
SMILES string	ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl
storage temp.	2-8°C

Application:	Triphosgene can be employed as a reagent to prepare: • Thiocarbonates from thiols and alcohols by one-pot, three-component reaction. • Substituted azetidin-2-ones from acids and imines via ketene–imine cycloaddition reaction. • Methyl (S)-2-isocyanato-3-phenylpropanoate from L-phenylalanine methyl ester hydrochloride in the presence of sodium bicarbonate. • Acyl azides derivatives from various carboxylic acids and sodium azide. • Immunosuppressant agent cyclosporin by solid-phase peptide synthesis. • Allyl azides from allyl alcohols and sodium azide in one pot method. • Esterification coupling reagent di-2-thienyl carbonate, from 2(5H)-thiophenone. • 2-Chloronicotinaldehydes via cyclization of the corresponding enamides.
General description:	Triphosgene [Bis(trichloromethyl)carbonate] is a versatile organic reagent used in organic synthesis alternative to phosgene. A catalytic amount of triphosgene is particularly used in chloroformylations, carbonylations, chlorinations, and dehydration reactions. It is also commonly employed as a coupling agent in the synthesis of carbonyl compounds.
Packaging:	5, 25, 100, 500 g in glass bottle

Symbol	GHS05,GHS06
Signal word	Danger
Hazard statements	H314 - H330
Precautionary statements	P260 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	T+
Risk Statements	26-34
Safety Statements	36/37/39-45
RIDADR	UN 2928 8(6.1) / PGII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98%
bp	203-206 °C (lit.)
mp	79-83 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352108

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