(2-Hydroxypropyl)-β-cyclodextrin

ALDRICH/332593 - average M_w ~1,380

Synonym: (2-Hydroxypropyl)-beta-cyclodextrin

CAS Number: 128446-35-5
EC Number: 420-920-1
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-332593-5G	5 g	$72.50 1/EA	Add To Favorites
45-332593-25G	25 g	$178.00 1/EA	Add To Favorites
45-332593-100G	100 g	$395.00 1/EA	Add To Favorites
45-332593-1KG	1 kg	$872.00 1/EA	Add To Favorites

ATR-IR Spectra for (2-Hydroxypropyl)-β-cyclodextrin.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: 332593-25G

Properties
Descriptions
Safety Info.
Basic Data

extent of labeling	0.6 molar substitution
form	powder
InChI	1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI key	ODLHGICHYURWBS-RYJYQAAZSA-N
mol wt	average M_w ~1,380
mp	278 °C (dec.)
optical activity	[α]26/D +139°, c = 1 in H₂O
Quality Level	200
SMILES string	CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
solubility	water: 180 g/L

Application:	HP-β-CD can be used: • As an additive in the separation of amino acids and lactic acids based on the coordination interactions between Cu²⁺ ions and analytes. • As a chiral selector in capillary electrophoresis, enabling the robust separation of diastereomeric derivatives of aspartic acid for analysis. • As a reagent to improve water solubility and anti-proliferative activity of pyrazolo[3,4-d] pyrimidines. • As formulation vehicle. It increases water solubility of the drug for successful delivery of medical agents to a biological system. • To increase the solubility of ropivacaine (RVC) upon complexation, which in turn enhances the pharmacological activity of RVC. • To increase the aqueous solubility of naproxen (NAP) in presence of polyvinylpyrrolidone (PVP). • As a template in the synthesis of hollow spherical copper sulfide nanoparticle assemblies.
Application:	The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
General description:	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) is a beta-cyclodextrin and hydroxyalkyl derivative and is widely used as a chiral solvent, phase transfer catalyst, and host molecule in organic synthesis. HP-β-CD can form inclusion complexes with guest molecules, which can help enhance the solubility, stability, and bioavailability of the guest molecule. It is an alternative to α-, β- and γ-cyclodextrin and exhibits a higher water solubility. HP-β-CD is commonly used as a drug solubilizer.
Packaging:	1 kg in poly drum
Packaging:	5, 25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	> 752.0 °F
Flash Point(C)	> 400 °C

mp	278 °C (dec.)
UNSPSC	12352302

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