(2-Hydroxypropyl)-β-cyclodextrin

ALDRICH/332607 - average M_w ~1,460

Synonym: (2-Hydroxypropyl)-beta-cyclodextrin; HP-β-CD

CAS Number: 128446-35-5
EC Number: 420-920-1
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-332607-5G	5 g	$67.90 1/EA	Add To Favorites
45-332607-25G	25 g	$178.00 1/EA	Add To Favorites
45-332607-100G	100 g	$385.00 1/EA	Add To Favorites
45-332607-500G	500 g	$1240.00 1/EA	Add To Favorites

ATR-IR Spectra for (2-Hydroxypropyl)-β-cyclodextrin.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 332607-500G

Properties
Descriptions
Safety Info.
Basic Data

extent of labeling	0.8 molar substitution
form	powder
InChI	1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI key	ODLHGICHYURWBS-RYJYQAAZSA-N
mol wt	average M_w ~1,460
mp	267 °C (dec.)
optical activity	[α]25/D +135°, c = 1 in H₂O (typical)
Quality Level	200
SMILES string	CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
solubility	water: 180 g/L

Application:	(2-Hydroxypropyl)-β-cyclodextrin may be used: • As an analytical standard for the determination of the analyte in pharmaceutical formulations by thin layer chromatography (TLC) method. • To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique. • As a mobile phase additive for the effective separation of β-carbolines by HPLC. • In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
Application:	The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
Application:	The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous solution because of the complex between HP-β-CD and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HP-β-CD that results in enhanced solubility. HP-β-CD can be used to prepare an inclusion complex with ropivacaine (RVC) to increase the solubility of RVC for efficient drug delivery.
General description:	(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.
Packaging:	5, 25, 100, 500 g in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	> 752.0 °F
Flash Point(C)	> 400 °C

mp	267 °C (dec.)
UNSPSC	12352201

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