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Methyl-β-cyclodextrin

ALDRICH/332615 - average Mn 1310

Synonym: MβCD; MβCD; MEBCD; Methyl-β-CD; Methyl-beta-cyclodextrin

CAS Number: 128446-36-6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-332615-5G 5 g
 $54.00
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45-332615-25G 25 g
 $176.00
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color white
extent of labeling 1.6-2.0 mol CH3 per unit anhydroglucose
form powder
InChI 1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
InChI key QGKBSGBYSPTPKJ-UHFFFAOYSA-N
mol wt average Mn 1310
mp 180-182 °C (lit.)
optical activity [α]25/D +159°, c = 1 in H2O
Application: Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Application: Methyl-β-cyclodextrin may be used as:
• A buffer additive for the effective separation of aminophospholipids by modified micellar electrokinetic capillary chromatography (MEKC) coupled with laser-induced fluorescence detection.
• A mobile phase additive for the analysis of R,S-naproxen mixtures in commercial tablet formulations by conventional and nano-liquid chromatography (nano-LC).
• An analytical standard for the determination of the analyte in biological samples by high performance liquid chromatography (HPLC).
• A chiral selector for the resolution of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis.
General description: Methyl-β-cyclodextrin (MβCD) is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilizing enzyme in organic solvents.
Other Notes: To gain a comprehensive understanding of our extensive range of Polysaccharides  for your research, we encourage you to visit our Carbohydrates  Category page.
Packaging: 5, 25 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) 368.6 °F
Flash Point(C) 187 °C
mp 180-182 °C (lit.)
UNSPSC 12352201

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