1-Boc-piperazine
ALDRICH/343536 - 97%
Synonym: tert-Butyl piperazine-
CAS Number: 57260-71-6
Empirical Formula (Hill Notation): C9H18N2O2
Molecular Weight: 186.25
MDL Number: MFCD00075265
Linear Formula: C9H18N2O2
Product Type: Chemical
| assay | 97% |
| form | solid |
| InChI | 1S/C9H18N2O2/c1-9(2,3)13- |
| InChI key | CWXPZXBSDSIRCS-UHFFFAOYSA |
| mp | 43-47 °C (lit.) |
| SMILES string | CC(C)(C)OC(=O)N1CCNCC1 |
| Application: | 1-Boc-piperazine may be used in: • preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives • termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization • preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors |
| General description: | 1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine. |
| Packaging: | 1, 5, 25 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | 235.4 °F - closed cup |
| Flash Point(C) | 113 °C - closed cup |
| Purity | 97% |
| mp | 43-47 °C (lit.) |
| UNSPSC | 12352100 |