Andrographolide

ALDRICH/365645 - 98%

Synonym: 3-dehydroandrographolide; Andrographis; Andrographiside aglycon

CAS Number: 5508-58-7
Empirical Formula (Hill Notation): C₂₀H₃₀O₅
Molecular Weight: 350.45
EC Number: 226-852-5
MDL Number: MFCD07778082
Linear Formula: C₂₀H₃₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-365645-100MG	100 mg	$59.00 1/EA	Add To Favorites
45-365645-500MG	500 mg	$222.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	98%
form	powder
functional group	ester
	hydroxyl
InChI	1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChI key	BOJKULTULYSRAS-OTESTREVSA-N
mp	229-232 °C (lit.)
optical activity	[α]20/D −126°, c = 1.5 in acetic acid
Quality Level	100
SMILES string	C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](CC=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

Application:	Andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening.: This study identifies potential andrographolide derivatives as innovative drug candidates that target the Keap1-Nrf2 pathway, crucial for antioxidant defense mechanisms. This approach highlights the compound′s versatility in developing treatments that could mitigate oxidative stress-related diseases, making it a significant area of interest for chemists and material scientists in both academia and biotech sectors (Jain and Sudandira Doss, 2023 ). TMT-based quantitative proteomics reveals the targets of andrographolide on LPS-induced liver injury.: This investigation into the proteomic changes induced by andrographolide in liver injury models offers insights into its therapeutic mechanisms, highlighting its potential as a treatment for inflammation and liver diseases, relevant for research and development in pharmaceutical and biochemical fields (Ge et al., 2023 ). Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics.: This study evaluates andrographolide’s roles within the context of its anticancer properties, providing a detailed analysis of its interactions at the molecular level, essential for material scientists and chemists working on novel cancer therapies (Zhao et al., 2023 ).
Biochem/physiol Actions:	Diterpenoid lactone with anti-inflammatory properties. It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement. Blocks the proliferation of several cancer cell lines in vitro.
General description:	Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus.
Packaging:	100 mg in clear glass bottle
Packaging:	500 mg in amber glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98%
mp	229-232 °C (lit.)
UNSPSC	12352005

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