3,4-Dihydroxybenzoic acid
ALDRICH/37580 - ≥97.0% (T)
Synonym: Protocatechuic acid
CAS Number: 99-50-3
Empirical Formula (Hill Notation): C7H6O4
Molecular Weight: 154.12
EC Number: 202-760-0
MDL Number: MFCD00002509
Linear Formula: (HO)2C6H3CO2H
Product Type: Chemical
| assay | ≥97.0% (T) |
| InChI | 1S/C7H6O4/c8-5-2-1-4(7(10 |
| InChI key | YQUVCSBJEUQKSH-UHFFFAOYSA |
| mp | 197-200 °C (dec.) (lit.) |
| SMILES string | OC(=O)c1ccc(O)c(O)c1 |
| Application: | 3,4-Dihydroxybenzoic acid is suitable for use in a study to investigate the effect of 4-coumaric and 3,4-dihydroxybenzoic acid on the basal oxidative DNA damage of rat colonic mucosa in vivo. It may be used in the derivatization of chitosan resin. |
| Biochem/physiol Actions: | Chemopreventive in several animal models of carcinogenesis. Blocks cell proliferation in the post-initiation phase. |
| General description: | 3,4-Dihydroxybenzoic acid is reported as dietery polyphenol. Antiviral activity of 3,4-dihydroxybenzoic acid (protocatechuic acid, PCA) against a virulent H9N2 strain in a mouse model is reported. Cytotoxic effects of PCA on 3 non-small cell lung cancer (NSCLC) cell lines, A549, H3255, and Calu-6 cell lines is reported. PCA is reported to prevent the carcinogenesis or antitumor growth in vivo. Signaling pathway involved in PCA-induced apoptosis in human gastric adenocarcinoma (AGS) cells is reported. The oxidation of 3,4-dihydroxybenzoic acid by H2O2 in aqueous/goethite slurry at varying operating conditions (catalyst load, temperature, pH, substrate and hydrogen peroxide starting concentration) is investigated. |
| Packaging: | 25, 100 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.0% (T) |
| mp | 197-200 °C (dec.) (lit.) |
| UNSPSC | 12352100 |