2-Imino-1-imidazolidineacetic acid

ALDRICH/377627 - 98%

Synonym: 1-Carboxymethyl-2-iminoimidazolidine; Cyclocreatine

CAS Number: 35404-50-3
Empirical Formula (Hill Notation): C₅H₉N₃O₂
Molecular Weight: 143.14
MDL Number: MFCD00134455
Linear Formula: C₅H₉N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-377627-1G	1 g	$147.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	98%
form	solid
functional group	carboxylic acid
InChI	1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10)
InChI key	AMHZIUVRYRVYBA-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(=O)CN1CCNC1=N
solubility	1 M HCl: soluble 25 mg/mL, clear, colorless

Application:	2-Imino-1-imidazolidineacetic acid (cyclocreatine) is suitable for use in a study to investigate the growth inhibitory effects of cyclocreatine on LS174T human colon adenocarcinoma implanted subdermally in nude mice. It may be used to evaluate the brain-type creatine kinase (CKB), to study the role of CKB in cigarette smoke-induced bronchial epithelial cell senescence.
Application:	Protectant against inhibition of cardiac mitochondrial respiration by methylglyoxal Growth inhibition of Hodgkin disease-derived cell lines Investigations into effects in rat hepatocarcinogenesis model
Biochem/physiol Actions:	Creatine analog that protects tissues from ischemic damage; decreases the rate of ATP production via creatine kinase and reduces the proliferation of tumor cell lines that are characterized by high levels of creatine kinase expression.
General description:	2-Imino-1-imidazolidineacetic acid (cyclocreatine) is an analog of creatine. It is reported to exhibit antitumour effect in some transplanted human and rodent tumours in vivo. It is reported as an efficient substrate for creatine kinase. It is an anticancer and neuroprotective agent. The crystal structure of cyclocreatine has been studied by X-ray diffraction methods. It is reported to crystallize as a zwitterion in the monoclinic system.
Packaging:	1 g in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98%
UNSPSC	12352100

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