2-Chloro-1,3,2-dioxaphospholane 2-oxide

ALDRICH/377953

Synonym: 2-Chloro-2-oxo-1,3,2-dioxaphospholane; Ethylene glycol chlorophosphate

CAS Number: 6609-64-9
Empirical Formula (Hill Notation): C₂H₄ClO₃P
Molecular Weight: 142.48
EC Number: 229-560-6
MDL Number: MFCD00043138
Linear Formula: C₂H₄ClO₃P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-377953-5G	5 g	$159.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

bp	89-91 °C/0.8 mmHg (lit.)
density	1.55 g/mL at 25 °C (lit.)
form	liquid
impurities	<10% 2-Chloro-1,3,2-dioxaphospholane
InChI	1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
InChI key	SBMUNILHNJLMBF-UHFFFAOYSA-N
mp	12-14 °C (neat) (lit.)
refractive index	n20/D 1.45 (lit.)
SMILES string	ClP1(=O)OCCO1
storage temp.	−20°C

Application:	2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of: • 2-methacryloyloxyethylphosphorylcholine • miltefosine (hexadecylphosphocholine, MT) analogs • phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester • uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC) • adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC) • structurally related phospholipids which are either conformationally restricted or flexible • phosphatidylcholines
Application:	Reactant for: • Synthesis of amino-functionalized hybrid hydrocarbon/fluorocarbon double-chain phospholipid • Synthesis of UV-polymerizable lipids via Chabrier reaction • Syntheses of block copolymers of poly(aliphatic ester) with clickable polyphosphoester • Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples • Synthesis of a zwitterionic silane • Synthesis of a core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery
General description:	2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen . 2-Chloro-1,3,2-dioxaphospholane 2-oxide is used in esterification reactions for cyclic phosphate synthesis, also reacts with phenyl grignard reagents.
Packaging:	5 g in glass bottle

Symbol	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P280 - P305 + P351 + P338 - P310
Hazard Codes	C
Risk Statements	14-34
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable
Supplemental Hazard Statements	EUH014

bp	89-91 °C/0.8 mmHg (lit.)
mp	12-14 °C (neat) (lit.)
Density	1.55 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.45 (lit.)
Storage Temp.	−20°C
UNSPSC	12352100

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