Chlorotrimethylsilane
ALDRICH/386529 - purified by redistillation, ≥99%
Synonym: TMSCl; TMCS; Trimethylchlorosilane; Trimethylsilyl chloride
CAS Number: 75-77-4
Empirical Formula (Hill Notation): C3H9ClSi
Molecular Weight: 108.64
EC Number: 200-900-5
MDL Number: MFCD00000502
Linear Formula: (CH3)3SiCl
Product Type: Chemical
4×100 Slip-cover Can
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
| assay | ≥99% |
| autoignition temp. | 752 °F |
| bp | 57 °C (lit.) |
| density | 0.856 g/mL at 25 °C (lit.) |
| expl. lim. | 6.4 % |
| form | liquid |
| impurities | <0.1% dichlorodimethylsilane |
| InChI | 1S/C3H9ClSi/c1-5(2,3)4/h1 |
| InChI key | IJOOHPMOJXWVHK-UHFFFAOYSA |
| mp | −40 °C (lit.) |
| purified by | glass distillation |
| redistillation | |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | C[Si](C)(C)Cl |
| vapor density | 3.7 (vs air) |
| vapor pressure | 100 mmHg ( 25 °C) |
| Application: | Chlorotrimethylsilane (TMSCl) can be used as: • A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines. • A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents. • A trapping agent for the anions generated during acyloin condensation reaction. • A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols. • A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters. • A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides. • A reagent in Fischer glycosidation. • A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et3SiH. • A reagent to synthesize sodium trimethylsilanethiolate (Me3SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me3SiSNa from foul-smelling bis(trimethylsilyl)sulfid |
| General description: | Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions. |
| Packaging: | 1, 2 L in Sure/Seal™ |
| Packaging: | 25, 100, 4×100 mL in Sure/Seal™ |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225 - H301 + H331 - H312 - H314 |
| Precautionary statements | P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | F,C |
| Risk Statements | 11-14-20/21/22-35-37 |
| Safety Statements | 7/9-16-26-36/37/39-45 |
| RIDADR | UN1298 - class 3 - PG 2 - Trimethylchlorosilane |
| WGK Germany | WGK 1 |
| Flash Point(F) | -18.4 °F - closed cup |
| Flash Point(C) | -28 °C - closed cup |
| Supplemental Hazard Statements | EUH014 |
| Purity | ≥99% |
| bp | 57 °C (lit.) |
| mp | −40 °C (lit.) |
| Density | 0.856 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352302 |