Suberohydroxamic acid

ALDRICH/390585 - 95%

Synonym: N,N′-Dihydroxyoctanediamide; SBHA; Suberoyl bis-hydroxamic acid

CAS Number: 38937-66-5
Empirical Formula (Hill Notation): C₈H₁₆N₂O₄
Molecular Weight: 204.22
MDL Number: MFCD00192455
Linear Formula: [-(CH₂)₃CONHOH]₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-390585-1G	1 g	$79.40 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	95%
InChI	1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI key	IDQPVOFTURLJPT-UHFFFAOYSA-N
mp	153-155 °C (lit.)
SMILES string	ONC(=O)CCCCCCC(=O)NO

Biochem/physiol Actions:	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC₅₀ values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Packaging:	1 g in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	95%
mp	153-155 °C (lit.)
UNSPSC	12352100

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