(DHQD)2PHAL
ALDRICH/392731 - ≥95%
Synonym: Hydroquinidine 1,4-phthalazinediyl diether
CAS Number: 140853-10-7
Empirical Formula (Hill Notation): C48H54N6O4
Molecular Weight: 778.98
MDL Number: MFCD00198107
Linear Formula: C48H54N6O4
Product Type: Chemical
12 Principles of Green Chemistry: Principle 1—Waste Prevention. This product has a smaller environmental footprint through reduction of waste in the manufacturing process.
12 Principles of Green Chemistry: Principle 3—Less Hazardous Chemical Syntheses. This product manufacturing process was designed with lesser toxicity to human health and the environment.
12 Principles of Green Chemistry: Principle 5—Safer Solvents and Auxiliaries. This product utilizes reduced volumes of auxiliary substances that are less hazardous.
12 Principles of Green Chemistry: Principle 12—Inherently Safer Chemistry for Accident Prevention. This product utilizes safer chemistry to minimize the potential for chemical accidents, including releases, explosions and fires.
| assay | ≥95% |
| form | powder |
| greener alternative category |  , Re-engineered |
| greener alternative product characteristics | Waste Prevention Less Hazardous Chemical Syntheses Safer Solvents and Auxiliaries Inherently Safer Chemistry for Accident Prevention Learn more about the Principles of Green Chemistry . |
| greener alternative product score | old score: 5 new score: 3 Find out more about DOZN™ Scoring |
| InChI | 1S/C48H54N6O4/c1-5-29-27- |
| InChI key | YUCBLVFHJWOYDN-HVLQGHBFSA |
| mp | 160 °C (dec.) (lit.) |
| optical activity | [α]22/D −262°, c = 1.2 in methanol |
| SMILES string | CC[C@H]1CN2CCC1CC2[C@@H]( |
| sustainability | Greener Alternative Product |
| Application: | (DHQD)2PHAL may be used as ligand for: • Osmium trioxide catalyzed asymmetric dihydroxylation of olefins. • Palladium catalyzed Suzuki-Miyaura coupling of aryl/heteroaryl halides with aryl boronic acids in aqueous medium and in the absence of phosphine/organic solvent. • Copper(I)-catalyzed azide-alkyne cycloaddition reaction to synthesize 1,2,3-triazoles in water. |
| Application: | Hydroquinidine 1,4-phthalazinediyl diether [(DHQD)2PHAL] can be used: • As a ligand for Sharpless asymmetric dihydroxylation. • For enantioselective α-fluorination of carbonyl compounds. |
| General description: | (DHQD)2PHAL is a dimer that can be used as a chiral amine catalyst for asymmetric halogenations. (DHQD)2PHAL is a modified cinchona alkaloid derivative mainly used as a ligand for enantioselective catalysis. |
| General description: | We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, "Safer Solvents and Auxiliaries" and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard. |
| Legal Information: | Sold under license from Rhodia Pharma Solutions. |
| Packaging: | 1 g in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| mp | 160 °C (dec.) (lit.) |
| UNSPSC | 12352005 |