N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
ALDRICH/394882 - >97%
Synonym: MTBSTFA
CAS Number: 77377-52-7
Empirical Formula (Hill Notation): C9H18F3NOSi
Molecular Weight: 241.33
MDL Number: MFCD00009671
Linear Formula: CF3CON(CH3)Si(CH3)2C(CH3)3
Product Type: Chemical
| assay | >97% |
| bp | 172-175 °C (lit.) |
| density | 1.036 g/mL at 25 °C (lit.) |
| form | liquid |
| functional group | amine |
| fluoro | |
| grade | derivatization grade |
| InChI | 1S/C9H18F3NOSi/c1-8(2,3)1 |
| InChI key | QRKUHYFDBWGLHJ-UHFFFAOYSA |
| Quality Level | 200 ![]() |
| refractive index | n |
| SMILES string | CN(C(=O)C(F)(F)F)[Si](C)( |
| storage temp. | 2-8°C |
| Application: | N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used:• As a derivatizing agent in the GC-MS analysis of hydroxylated fluorenes and in the GC analysis of amino acids. • As an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides. • To functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups. MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization. |
| General description: | N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly reactive silylating reagent commonly used for silyation of carboxylic acids, alcohols, amines, and thiols. It is also used as a protection, deprotection reagent. |
| Packaging: | 10×1 mL in ampule |
| Packaging: | 5, 25, 100 mL in glass bottle |
| Symbol | GHS02 |
| Signal word | Warning |
| Hazard statements | H226 |
| Precautionary statements | P210 - P233 - P240 - P241 - P242 - P243 |
| Hazard Codes | Xi |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 26 |
| RIDADR | UN 1993C 3 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 113.0 °F - closed cup |
| Flash Point(C) | 45 °C - closed cup |
| Purity | >97% |
| bp | 172-175 °C (lit.) |
| Density | 1.036 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352001 |


