Polyethylenimine, branched

ALDRICH/408727 - average M_w ~25,000 by LS, average M_n ~10,000 by GPC, branched

Synonym: aziridine, homopolymer; PEI

CAS Number: 9002-98-6
MDL Number: MFCD00084427
Linear Formula: H(NHCH₂CH₂)_nNH₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-408727-100ML	100 mL	$95.40 1/EAAdd To Favorites		Add To Favorites
45-408727-250ML	250 mL	$171.00 1/EAAdd To Favorites		Add To Favorites
45-408727-1L	1 L	$464.00 1/EAAdd To Favorites		Add To Favorites

bp	250 °C (lit.)
density	1.030 g/mL at 25 °C
form	viscous liquid
impurities	≤1% water
InChI	1S/C2H5N/c1-2-3-1/h3H,1-2H2
InChI key	NOWKCMXCCJGMRR-UHFFFAOYSA-N
mol wt	average M_n ~10,000 by GPC
	average M_w ~25,000 by LS
Quality Level	200
refractive index	n20/D 1.5290
SMILES string	C1CN1
viscosity	13,000-18,000(50 °C)

Application:	Polyethyleneimine can be used as a non-viral synthetic polymer vector for in vivo delivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity. PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO₂ absorption and gene delivery. Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.
Features and Benefits:	Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties. Branched PEI has better complexation andbuffering capacity.
General description:	Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.
Packaging:	1 L in poly bottle
Packaging:	100, 250 mL in poly bottle
Physical form:	Branched polymer

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H317 - H319 - H411
Precautionary statements	P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xn,N
Risk Statements	22-43-51/53
Safety Statements	37-61
RIDADR	UN 3082 9 / PGIII
WGK Germany	WGK 2