Diallyl N,N-diisopropylphosphoramidite

ALDRICH/439606

Synonym: N,N-Bis(1-methylethyl)phosphoramidous acid di-2-propenyl ester; Diallyloxy(diisopropylamino)phosphine

CAS Number: 126429-21-8
Empirical Formula (Hill Notation): C₁₂H₂₄NO₂P
Molecular Weight: 245.30
MDL Number: MFCD00216647
Linear Formula: [(CH₃)₂CH]₂NP(OCH₂CH=CH₂)₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-439606-1G	1 g	$345.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

bp	130 °C (lit.)
density	0.928 g/mL at 25 °C (lit.)
form	liquid
functional group	amine
InChI	1S/C12H24NO2P/c1-7-9-14-16(15-10-8-2)13(11(3)4)12(5)6/h7-8,11-12H,1-2,9-10H2,3-6H3
InChI key	QBLCHHSGJTUNSJ-UHFFFAOYSA-N
Quality Level	200
refractive index	n20/D 1.456 (lit.)
SMILES string	CC(C)N(C(C)C)P(OCC=C)OCC=C
storage temp.	2-8°C

Application:	Diallyl N,N-diisopropylphosphoramidite may be employed as phophorylating reagent in the following studies: • Preparation of peptide substrates. • Preparation of rhodamine dyes with phosphorylated CH₂OH sites. • Synthesis of 3-[4-(bis-allyloxy-phosphoryloxy)-2(R)-hydroxy-3,3-dimethyl-butyrylamino]-thiopropionic acid-S-propylester.
Application:	Precursor involved in the synthesis of pharmacologically active molecules including: • Selective orally active S1P1 agonists • Water-soluble prodrugs of triazole CS-758 with antifungal activity • Fostriecin analogs as antitumor agents Reactant involved in: • Phosphitylation of alcohols • Deallylation for the synthesis of nucleoside phosphoramidite • Posphitylation and stereoselective Pudovik rearrangement
Packaging:	1 g in glass bottle

Symbol	GHS02,GHS07
Signal word	Warning
Hazard statements	H226 - H315 - H319 - H335
Precautionary statements	P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	10-36/37/38
Safety Statements	26-36
RIDADR	UN 1993C 3 / PGIII
WGK Germany	WGK 3
Flash Point(F)	89.6 °F - closed cup
Flash Point(C)	32 °C - closed cup

bp	130 °C (lit.)
Density	0.928 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.456 (lit.)
Storage Temp.	2-8°C
UNSPSC	12352100

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