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Fmoc-Ser(tBu)-OH

ALDRICH/47619 - ≥98.0% (HPLC)

Synonym: Fmoc-O-tert-butyl-L-serine

CAS Number: 71989-33-8
Empirical Formula (Hill Notation): C22H25NO5
Molecular Weight: 383.44
EC Number: 276-260-6
MDL Number: MFCD00037127
Linear Formula: C22H25NO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-47619-10G-F 10 g
 $70.00
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45-47619-25G-F 25 g
 $93.70
1/EA		 Add To Favorites
45-47619-100G-F 100 g
 $332.00
1/EA		 Add To Favorites

 

application(s) peptide synthesis
assay ≥98.0% (HPLC)
form powder
functional group Fmoc
InChI 1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
InChI key REITVGIIZHFVGU-IBGZPJMESA-N
optical activity [α]20/D +25.5±1°, c = 1% in ethyl acetate
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
SMILES string CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
storage temp. 2-8°C
Application: Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:
• Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
• Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
• Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.
Packaging: 10, 25 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352209

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