Synonym: 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
CAS Number: 99569-11-6
Empirical Formula (Hill Notation): C4H8O3
Molecular Weight: 104.10
MDL Number: MFCD10039829
Linear Formula: C4H8O3
Product Type: Chemical
| assay |
≥98.0% (GC) |
| bp |
192-193 °C (lit.) |
| composition |
4-hydroxymethyl-1,3-dioxolane, ~40% |
| |
5-hydroxy-1,3-dioxane, ~60% |
| contains |
~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer |
| density |
1.203 g/mL at 25 °C (lit.) |
| InChI |
1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2 |
| InChI key |
JIUMSISXCKWZTA-UHFFFAOYSA-N |
| refractive index |
n20/D 1.451 |
| |
n20/D 1.451 (lit.) |
| SMILES string |
OCC1COCO1.OC2COCOC2 |
| Application: |
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats. |
| Application: |
Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes. |
| General description: |
Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported. |
| Packaging: |
100, 500 mL in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H319 |
| Precautionary statements |
P305 + P351 + P338 |
| Hazard Codes |
Xi |
| Risk Statements |
36 |
| Safety Statements |
26 |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
199.4 °F - closed cup |
| Flash Point(C) |
93 °C - closed cup |
| Purity |
≥98.0% (GC) |
| bp |
192-193 °C (lit.) |
| Density |
1.203 g/mL at 25 °C (lit.) |
| Refractive Index |
n20/D 1.451 (lit.); n20/D 1.451 |
| UNSPSC |
12352100 |
