2-Chlorotrityl chloride, polymer-bound
ALDRICH/532282 - 200-400 mesh, extent of labeling: 0.3-0.8 mmol/g Cl loading, 2 % cross-linked
Synonym: 2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
CAS Number: 42074-68-0
MDL Number: MFCD00040399
Product Type: Chemical
| application(s) | peptide synthesis |
| crosslinking | 2 % cross-linked |
| extent of labeling | 0.3-0.8 mmol/g Cl loading |
| InChI | 1S/C19H14Cl2/c20-18-14-8- |
| InChI key | JFLSOKIMYBSASW-UHFFFAOYSA |
| particle size | 200-400 mesh |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| SMILES string | Clc1ccccc1C(Cl)(c2ccccc2) |
| Application: | • Acid labile resin used in Fmoc-based solid phase peptide synthesis. • Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired. • 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys). • This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use: • Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane. • Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v). • Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately. • If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity. |
| Packaging: | 5 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| UNSPSC | 12352107 |