L-Lysine-13C6,15N2 hydrochloride
ALDRICH/608041 - 99 atom % 13C, 99 atom % 15N, 95% (CP)
Synonym: SILAC Amino Acid; (S)-2,6-Diaminohexanoic acid-13C6,15N2 hydrochloride; 13C and 15N Labeled Lys; 13C and 15N Labeled lysine hydrochloride
CAS Number: 1200447-00-2
Empirical Formula (Hill Notation): 13C6H15Cl15N2O2
Molecular Weight: 190.59
MDL Number: MFCD00144647
Linear Formula: H215N(13CH2)413CH(15NH2)13CO2H · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 608041-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 608041-2G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 608041-250MG
| assay | 95% (CP) |
| form | solid |
| InChI | 1S/C6H14N2O2.ClH/c7-4-2-1 |
| InChI key | BVHLGVCQOALMSV-GSMNGUNQSA |
| isotopic purity | 99 atom % 13C |
| 99 atom % 15N | |
| mass shift | M+8 |
| mp | 263-264 °C (dec.) (lit.) |
| optical activity | [α]25/D +20.7°, c = 2 in 5 M HCl |
| Quality Level | 200  |
| SMILES string | Cl.[15NH2][13CH2][13CH2][ |
| technique(s) | bio NMR: suitable |
| protein expression: suitable |
| Application: | • L-Lysine-13C6,15N2 hydrochloride has been used in pSILAC (pulsed stable isotope labeling by amino acids in cell culture) mass spectrometry to study protein profile in cells transfected with microRNAs. • It has been used in SILAC isotopic labeling for the characterization of lysine racemase. • It has been used in SILAC labeling for phosphoproteomic measurements in neuro-2a cells treated with and without GFKP-19 (2-pyrrolidone derivative). |
| Application: | Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages. |
| General description: | Lysine is a basic ketogenic amino acid with a protonated alkyl amino group. Lysine degradation results in the formation of acetoacetate. Acetylation/deacetylation of lysine residues in histones is a mechanism to regulate chromatin organization in eukaryotes. Isotope labeled amino acids are required for the production of isotopically labeled proteins. |
| Packaging: | 1, 2 g in glass bottle |
| Packaging: | 100, 250 mg in glass bottle |
| Packaging: | This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service . |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 95% (CP) |
| mp | 263-264 °C (dec.) (lit.) |
| UNSPSC | 12352209 |